Role of HDL apolipoprotein E in cellular cholesterol efflux: studies in apo E knockout transgenic mice.

@article{Hayek1994RoleOH,
  title={Role of HDL apolipoprotein E in cellular cholesterol efflux: studies in apo E knockout transgenic mice.},
  author={Tony El Hayek and J. Oiknine and Jacqueline Brook and Michael Y Aviram},
  journal={Biochemical and biophysical research communications},
  year={1994},
  volume={205 2},
  pages={
          1072-8
        }
}
The role of apo E in aspects of reverse cholesterol transport was studied in apolipoprotein E-deficient mice. These animals develop rampant atherosclerosis. The efflux of cholesterol from mouse peritoneal macrophages (MPM) was 40% lower when induced by high density lipoprotein (HDL) from apo E-deficient mice, compared to the effect of HDL from normal mice. On adding apo E to apo E-deficient HDL, cholesterol efflux from the macrophages increased by 35%, approaching the degree of efflux obtained… CONTINUE READING
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