Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation.

  title={Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation.},
  author={Michael R. H{\"u}bner and David L. Spector},
  journal={Cold Spring Harbor symposia on quantitative biology},
The influence of histone amino-terminal covalent modifications on gene regulation has drawn intense research efforts in recent years. It is now clear that activating and inactivating modifications have a key role in determining the gene-expression profile of an individual cell or cell lineage. Thus, differences in these modifications have a pivotal role in determining and maintaining cell fate during development. The interplay of histone methyltransferases (HMTs) and demethylases confers the… CONTINUE READING

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