Role of H2-calponin in regulating macrophage motility and phagocytosis.

  title={Role of H2-calponin in regulating macrophage motility and phagocytosis.},
  author={Qi Huang and Muhammad M. Hossain and Kaichun Wu and Kakoli Parai and Richard M. Pope and Jian-Ping Jin},
  journal={The Journal of biological chemistry},
  volume={283 38},
The actin cytoskeleton plays a major role in cell motility that is essential for the function of phagocytes. Calponin is an actin-associated regulatory protein. Here we report the finding of significant levels of the h2 isoform of calponin in peripheral blood cells of myeloid lineage. To study the functional significance, h2-calponin gene (Cnn2) interrupted mice were constructed. Germ line transmission of the Cnn2-flox-neo allele was obtained in chimeras from two independent clones of targeted… CONTINUE READING
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