Role of Granulocyte-Macrophage Colony-Stimulating Factor Production by T Cells during Mycobacterium tuberculosis Infection

@inproceedings{Rothchild2017RoleOG,
  title={Role of Granulocyte-Macrophage Colony-Stimulating Factor Production by T Cells during Mycobacterium tuberculosis Infection},
  author={Alissa C. Rothchild and Britni L. Stowell and Girija Goyal and Cl{\'a}udio Nunes-Alves and Qianting Yang and Kadamba Papavinasasundaram and Christopher M. Sassetti and Glenn Dranoff and Xinchun Chen and Jinhee Lee and Samuel M Behar},
  booktitle={mBio},
  year={2017}
}
Mice deficient for granulocyte-macrophage colony-stimulating factor (GM-CSF-/-) are highly susceptible to infection with Mycobacterium tuberculosis, and clinical data have shown that anti-GM-CSF neutralizing antibodies can lead to increased susceptibility to tuberculosis in otherwise healthy people. GM-CSF activates human and murine macrophages to inhibit intracellular M. tuberculosis growth. We have previously shown that GM-CSF produced by iNKT cells inhibits growth of M. tuberculosis However… CONTINUE READING