Role of Glycogen Synthase Kinase-3 in Cardioprotection

@inproceedings{Juhaszova2009RoleOG,
  title={Role of Glycogen Synthase Kinase-3 in Cardioprotection},
  author={Magdalena Juhaszova and D B Zorov and Yael Yaniv and H. Bradley Nuss and Su Xing Wang and Steven J. Sollott},
  year={2009}
}
Limitation of infarct size by ischemic/pharmacological preand postconditioning involves activation of a complex set of cell-signaling pathways. Multiple lines of evidence implicate the mitochondrial permeability transition pore (mPTP) as a key end effector of ischemic/pharmacological preand postconditioning. Increasing the ROS threshold for mPTP induction enhances the resistance of cardiomyocytes to oxidant stress and results in infarct size reduction. Here, we survey and synthesize the present… CONTINUE READING

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