Role of Glutathione in the Regulation of Cisplatin Resistance in Cancer Chemotherapy

Abstract

Three mechanisms have been proposed for the role of glutathione (GSH) in regulating cisplatin (CDDP) sensitivities that affects its ultimate cell-killing ability: (i) GSH may serve as a cofactor in facilitating multidrug resistance protein 2- (MRP2-) mediated CDDP efflux in mammalian cells, since MRP2-transfected cells were shown to confer CDDP resistance… (More)
DOI: 10.1155/2010/430939

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