Role of Glutamatergic System in Obsessive-Compulsive Disorder with Possible Therapeutic Implications.

@article{Vlcek2018RoleOG,
  title={Role of Glutamatergic System in Obsessive-Compulsive Disorder with Possible Therapeutic Implications.},
  author={Premysl Vlcek and Jakub Pol{\'a}k and Martin Brunovsky and Jiř{\'i} Hor{\'a}{\vc}ek},
  journal={Pharmacopsychiatry},
  year={2018},
  volume={51 6},
  pages={
          229-242
        }
}
Obsessive-compulsive disorder (OCD) is a chronic psychiatric illness and 1 of the most common anxiety disorders with the prevalence of 3%. Although its pathogenesis remains unclear, the traditional model focused on alternations in the serotonin system. Selective serotonin reuptake inhibitors provide the most effective treatment; however, as much as 40-60% of patients do not respond to antidepressants therapy. Thus, attention has shifted towards other neurotransmitter systems and related… 
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NDT_A_211703 1003..1013
*These authors contributed equally to this work Abstract: Glutamate is a ubiquitous excitatory neurotransmitter, which is involved in normal physiology, a variety of central nervous system (CNS)
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