Role of Glutamatergic System in Obsessive-Compulsive Disorder with Possible Therapeutic Implications.

  title={Role of Glutamatergic System in Obsessive-Compulsive Disorder with Possible Therapeutic Implications.},
  author={Premysl Vlcek and Jakub Pol{\'a}k and Martin Brunovsky and Jiř{\'i} Hor{\'a}{\vc}ek},
  volume={51 6},
Obsessive-compulsive disorder (OCD) is a chronic psychiatric illness and 1 of the most common anxiety disorders with the prevalence of 3%. Although its pathogenesis remains unclear, the traditional model focused on alternations in the serotonin system. Selective serotonin reuptake inhibitors provide the most effective treatment; however, as much as 40-60% of patients do not respond to antidepressants therapy. Thus, attention has shifted towards other neurotransmitter systems and related… 
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NDT_A_211703 1003..1013
*These authors contributed equally to this work Abstract: Glutamate is a ubiquitous excitatory neurotransmitter, which is involved in normal physiology, a variety of central nervous system (CNS)
Forgetting Unwanted Memories: Active Forgetting and Implications for the Development of Psychological Disorders
Recent findings on deficits in active forgetting observed in psychopathologies, like post-traumatic stress disorder, depression, schizophrenia, and obsessive-compulsive disorder are described and the role of neurotransmitter systems, known to be involved in the pathogenesis of mental disorders, has been investigated inactive forgetting paradigms.
Resolution of Inappropriate Sexual Behavior in an Elderly Male with Intellectual Disability with Memantine: Case Report, and Review of the Literature
resolution of new onset inappropriate sexual behavior (ISB) with memantine in a 67 year old male with intellectual disability and comorbid mood disorder, is a previously unreported therapeutic effect of memantine.


Obsessive compulsive disorder and the glutamatergic system
There is a need for additional pharmacotherapy trials on glutamatergic agents in OCD, and possible research designs for such trials might include stand-alone approaches, pharmacotherapy augmentation, or psychotherapeutic augmentation.
The role of glutamate signaling in the pathogenesis and treatment of obsessive–compulsive disorder
Glutamate modulators in the treatment of obsessive-compulsive disorder.
Investigations of memantine, riluzole, ketamine, D-cycloserine, glycine, N-acetylserine, topiramate, and lamotrigine find evidence for benefit in some patients; though none has been proven effective with sufficient clarity to be considered part of standard care, they are options in individuals whose symptoms are refractory to better-established therapeutic strategies.
Glutamatergic agents for OCD and related disorders
  • C. Pittenger
  • Biology, Psychology
    Current Treatment Options in Psychiatry
  • 2015
It is notable that these agents all work by different, and in some cases opposite, mechanisms; this suggests that the authors have much to learn about the role of glutamate dysregulation in the etiology of OCD and of glutamate modulators in its treatment.
Updated overview of the putative role of the serotoninergic system in obsessive-compulsive disorder
The development of new neurochemical probes that explore the sensitivity of various 5HT receptor subtypes has provided precious information, and suggests the potential implication of the 5HT1D receptor, as shown by the aggravation of OC manifestations in response to sumatriptan, a selective 5HT 1D receptor agonist.
Glutamatergic modulatory therapy for Tourette syndrome.
Neurobiological model of obsessive–compulsive disorder: Evidence from recent neuropsychological and neuroimaging findings
Evidence from fMRI studies suggests that broader regions, including dorsolateral prefrontal and posterior regions, might be involved in the pathophysiology of OCD, which is heterogeneous and might have several different neural systems related to clinical factors, such as symptom dimensions.
Quantitative Electroencephalography in OCD Patients Treated with Paroxetine
The effectiveness of drugs that have a specific effect on the activity of the serotonergic neurotransmitter system has changed the outlook for patients suffering from obsessive-compulsive disorder
Quantitative electroencephalographic subtyping of obsessive-compulsive disorder