Role of Gi Proteins in the Antidepressant-like Effect of Amitriptyline and Clomipramine

The effect of the i.c.v. administration of pertussis toxin (PTX) and antisense oligodeoxynucleotides directed against the α subunit of different Gi-proteins (anti-Giα1, anti-Giα2, anti-Giα3, anti-Goα1, anti-Goα2) on the antidepressant-like effect induced by amitriptyline and clomipramine, was evaluated in the mouse forced swimming test, an animal model of… CONTINUE READING