Role of Germination in Murine Airway CD8+ T-Cell Responses to Aspergillus Conidia

@inproceedings{Templeton2011RoleOG,
  title={Role of Germination in Murine Airway CD8+ T-Cell Responses to Aspergillus Conidia},
  author={Steven P. Templeton and Amanda D. Buskirk and Brandon F Law and Brett Green and Donald H. Beezhold},
  booktitle={PloS one},
  year={2011}
}
Pulmonary exposure to Aspergillus fumigatus has been associated with morbidity and mortality, particularly in immunocompromised individuals. A. fumigatus conidia produce β-glucan, proteases, and other immunostimulatory factors upon germination. Murine models have shown that the ability of A. fumigatus to germinate at physiological temperature may be an important factor that facilitates invasive disease. We observed a significant increase in IFN-γ-producing CD8(+) T cells in bronchoalveolar… CONTINUE READING