Role of Genotype in the Cycle of Violence in Maltreated Children
@article{Caspi2002RoleOG, title={Role of Genotype in the Cycle of Violence in Maltreated Children}, author={A. Caspi and J. McClay and T. Moffitt and J. Mill and J. Martin and I. Craig and A. Taylor and R. Poulton}, journal={Science}, year={2002}, volume={297}, pages={851 - 854} }
We studied a large sample of male children from birth to adulthood to determine why some children who are maltreated grow up to develop antisocial behavior, whereas others do not. A functional polymorphism in the gene encoding the neurotransmitter-metabolizing enzyme monoamine oxidase A (MAOA) was found to moderate the effect of maltreatment. Maltreated children with a genotype conferring high levels of MAOA expression were less likely to develop antisocial problems. These findings may partly… CONTINUE READING
Topics from this paper
Paper Mentions
News Article
Observational Clinical Trial
The aims of this study are two fold: To show whether there is an increased environmental or
genetic susceptibility to stress in patients with T1D and whether it influences diabetes… Expand
Conditions | Stress, Type 1 Diabetes |
---|---|
Intervention | Behavioral, Genetic, Procedure |
3,977 Citations
Child maltreatment moderates the association of MAOA with symptoms of depression and antisocial personality disorder.
- Psychology, Medicine
- Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association
- 2010
- 89
MAOA Genotype, Childhood Maltreatment, and Their Interaction in the Etiology of Adult Antisocial Behaviors
- Psychology, Medicine
- Biological Psychiatry
- 2014
- 64
- Highly Influenced
- PDF
Sexually harmful behaviour in young children and the link to maltreatment in early childhood
- 2009
- 1
- PDF
Childhood Maltreatment, Subsequent Antisocial Behavior, and the Role of Monoamine Oxidase A Genotype
- Psychology, Medicine
- Biological Psychiatry
- 2006
- 161
MAOA Genotype, Maltreatment, and Aggressive Behavior: The Changing Impact of Genotype at Varying Levels of Trauma
- Psychology, Medicine
- Biological Psychiatry
- 2009
- 174
Effects of the MAOA gene and levels of exposure to violence on antisocial outcomes
- Medicine, Psychology
- British Journal of Psychiatry
- 2016
- 32
- PDF
Examining the association between MAOA genotype and incarceration, anger and hostility: The moderating influences of risk and protective factors
- Psychology
- 2011
- 18
MAOA, Childhood Maltreatment, and Antisocial Behavior: Meta-analysis of a Gene-Environment Interaction
- Psychology, Medicine
- Biological Psychiatry
- 2014
- 238
- Highly Influenced
References
SHOWING 1-10 OF 73 REFERENCES
The timing of child physical maltreatment: a cross-domain growth analysis of impact on adolescent externalizing and internalizing problems.
- Psychology, Medicine
- Development and psychopathology
- 2001
- 280
Twin studies of psychiatric illness: an update.
- Psychology, Medicine
- Archives of general psychiatry
- 2001
- 351
- PDF
The impact of child maltreatment and psychopathology on neuroendocrine functioning.
- Psychology, Medicine
- Development and psychopathology
- 2001
- 398
Developmental traumatology: the psychobiological development of maltreated children and its implications for research, treatment, and policy.
- Psychology
- 2001
- 533
Child abuse and neglect and the brain--a review.
- Psychology, Medicine
- Journal of child psychology and psychiatry, and allied disciplines
- 2000
- 720
- PDF
Neuroendocrine response to fenfluramine challenge in boys. Associations with aggressive behavior and adverse rearing.
- Psychology, Medicine
- Archives of general psychiatry
- 1997
- 116