Role of Genotype in the Cycle of Violence in Maltreated Children

  title={Role of Genotype in the Cycle of Violence in Maltreated Children},
  author={A. Caspi and J. McClay and T. Moffitt and J. Mill and J. Martin and I. Craig and A. Taylor and R. Poulton},
  pages={851 - 854}
  • A. Caspi, J. McClay, +5 authors R. Poulton
  • Published 2002
  • Medicine, Psychology
  • Science
  • We studied a large sample of male children from birth to adulthood to determine why some children who are maltreated grow up to develop antisocial behavior, whereas others do not. A functional polymorphism in the gene encoding the neurotransmitter-metabolizing enzyme monoamine oxidase A (MAOA) was found to moderate the effect of maltreatment. Maltreated children with a genotype conferring high levels of MAOA expression were less likely to develop antisocial problems. These findings may partly… CONTINUE READING
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