Role of Genotype in the Cycle of Violence in Maltreated Children

  title={Role of Genotype in the Cycle of Violence in Maltreated Children},
  author={Avshalom Caspi and Joseph L. McClay and Terrie E. Moffitt and Jonathan S Mill and Judy L. Martin and Ian W. Craig and Alan H. Taylor and Richie Poulton},
  pages={851 - 854}
We studied a large sample of male children from birth to adulthood to determine why some children who are maltreated grow up to develop antisocial behavior, whereas others do not. A functional polymorphism in the gene encoding the neurotransmitter-metabolizing enzyme monoamine oxidase A (MAOA) was found to moderate the effect of maltreatment. Maltreated children with a genotype conferring high levels of MAOA expression were less likely to develop antisocial problems. These findings may partly… 

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Non-linear interactions between the MAOA gene and violence were detected, suggesting that the genetic moderation may come about once a certain level of violence is experienced, and future studies should investigate the mechanisms translating substantial violence exposure.

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Interaction between MAO-A genotype and maltreatment in the risk for conduct disorder: failure to confirm in adolescent patients

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Interaction between MAO-A genotype and maltreatment in the risk for conduct disorder: failure to confirm in adolescent patients.

The results of the current study do not support the hypothesis that a polymorphism in the gene encoding MAO-A contributes to the genetic risk for conduct disorder.



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The results demonstrated that the earlier children experienced harsh physical treatment by significant adults, the more likely they were to experience adjustment problems in early adolescence.

Twin studies of psychiatric illness: an update.

  • K. Kendler
  • Psychology
    Archives of general psychiatry
  • 2001
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The cycle of violence.

Findings from a cohort study show that being abused or neglected as a child increases one's risk for delinquency, adult criminal behavior, and violent criminal behavior; however, the majority of abused and neglected children do not become delinquent, criminal, or violent.

Handbook of antisocial behavior

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Evidence is reported suggesting that a mutation in the gene for monoamine oxidase A (MAOA) may underlie the aggressive and sometimes violent behavior displayed by certain males in this family.

Antisocial behavior by young people.

1. Introduction 2. Identifying the most useful research 3. Concepts and measures of crime 4. Historical trends 5. Varieties of antisocial behaviour 6. The role of individual features 7. The role of

Child abuse and neglect and the brain--a review.

  • D. Glaser
  • Psychology
    Journal of child psychology and psychiatry, and allied disciplines
  • 2000
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Neuroendocrine response to fenfluramine challenge in boys. Associations with aggressive behavior and adverse rearing.

In young boys, aggressive behavior and social circumstances that are conducive to the development of aggressive behavior are positively correlated with a marker of central serotonergic activity.