Role of Genotype in the Cycle of Violence in Maltreated Children
@article{Caspi2002RoleOG,
title={Role of Genotype in the Cycle of Violence in Maltreated Children},
author={A. Caspi and J. McClay and T. Moffitt and J. Mill and J. Martin and I. Craig and A. Taylor and R. Poulton},
journal={Science},
year={2002},
volume={297},
pages={851 - 854}
}We studied a large sample of male children from birth to adulthood to determine why some children who are maltreated grow up to develop antisocial behavior, whereas others do not. A functional polymorphism in the gene encoding the neurotransmitter-metabolizing enzyme monoamine oxidase A (MAOA) was found to moderate the effect of maltreatment. Maltreated children with a genotype conferring high levels of MAOA expression were less likely to develop antisocial problems. These findings may partly… CONTINUE READING
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References
SHOWING 1-10 OF 73 REFERENCES
The timing of child physical maltreatment: a cross-domain growth analysis of impact on adolescent externalizing and internalizing problems.
- Psychology, Medicine
- Development and psychopathology
- 2001
- 280
Twin studies of psychiatric illness: an update.
- Psychology, Medicine
- Archives of general psychiatry
- 2001
- 351
- PDF
The impact of child maltreatment and psychopathology on neuroendocrine functioning.
- Psychology, Medicine
- Development and psychopathology
- 2001
- 398
Developmental traumatology: the psychobiological development of maltreated children and its implications for research, treatment, and policy.
- Psychology
- 2001
- 533
Child abuse and neglect and the brain--a review.
- Psychology, Medicine
- Journal of child psychology and psychiatry, and allied disciplines
- 2000
- 720
- PDF
Neuroendocrine response to fenfluramine challenge in boys. Associations with aggressive behavior and adverse rearing.
- Psychology, Medicine
- Archives of general psychiatry
- 1997
- 116