Role of Genetics and Epigenetics in Mucosal, Uveal, and Cutaneous Melanomagenesis.

@article{Venza2016RoleOG,
  title={Role of Genetics and Epigenetics in Mucosal, Uveal, and Cutaneous Melanomagenesis.},
  author={Mario Venza and Maria Visalli and Concetta Beninati and Carmelo Biondo and Diana Teti and Isabella Venza},
  journal={Anti-cancer agents in medicinal chemistry},
  year={2016},
  volume={16 5},
  pages={528-38}
}
Melanoma prevalently occurs on parts of the body that have been overexposed to the sun. However, it can also originate in the nervous system, eye and mucous membranes. Melanoma has been thought for a long time to arise through a series of genetic mechanisms involving numerous irreversible changes within the human genome. However, recently, "epimutations" have attracted considerable attention owing to their high prevalence rate and reversible nature. These observations opened up new perspectives… CONTINUE READING
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