Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy.

@article{AngelilloScherrer2005RoleOG,
  title={Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy.},
  author={Anne Angelillo-Scherrer and Laurent Burnier and Nathalie Flores and Pierre Savi and M Demol and Paul Schaeffer and J C Herbert and Greg Lemke and Stephen P Goff and Glenn K. Matsushima and H. Shelton Earp and Christian Vesin and Marc F Hoylaerts and St{\'e}phane Plaisance and D{\'e}sir{\'e} Collen and Edward M Conway and Bernhard Wehrle-Haller and Peter Carmeliet},
  journal={The Journal of clinical investigation},
  year={2005},
  volume={115 2},
  pages={
          237-46
        }
}
Mechanisms regulating thrombus stabilization remain largely unknown. Here, we report that loss of any 1 of the Gas6 receptors (Gas6-Rs), i.e., Tyro3, Axl, or Mer, or delivery of a soluble extracellular domain of Axl that traps Gas6 protects mice against life-threatening thrombosis. Loss of a Gas6-R does not prevent initial platelet aggregation but impairs subsequent stabilization of platelet aggregates, at least in part by reducing "outside-in" signaling and platelet granule secretion. Gas6… CONTINUE READING
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Conflict of interest: The authors have declared that no conflict of interest exists

A thromboxane
Citation for this article: J. Clin. Invest • 2005