Role of Gap Junction Protein Connexin43 in Astrogliosis Induced by Brain Injury

@inproceedings{Theodoric2012RoleOG,
  title={Role of Gap Junction Protein Connexin43 in Astrogliosis Induced by Brain Injury},
  author={Nicolas Theodoric and John F. Bechberger and Christian C. Naus and Wun-Chey Sin},
  booktitle={PloS one},
  year={2012}
}
Astrogliosis is a process that involves morphological and biochemical changes associated with astrocyte activation in response to cell damage in the brain. The upregulation of intermediate filament proteins including glial fibrillary acidic protein (GFAP), nestin and vimentin are often used as indicators for astrogliosis. Although connexin43 (Cx43), a channel protein widely expressed in adult astrocytes, exhibits enhanced immunoreactivity in the peri-lesion region, its role in astrogliosis is… CONTINUE READING
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