Role of GPR30 in mediating estradiol effects on acetylcholine release in the hippocampus.

@article{Gibbs2014RoleOG,
  title={Role of GPR30 in mediating estradiol effects on acetylcholine release in the hippocampus.},
  author={Robert B. Gibbs and Doug D Nelson and Rebecca F. Hammond},
  journal={Hormones and behavior},
  year={2014},
  volume={66 2},
  pages={339-45}
}
We have hypothesized that estradiol enhances basal forebrain cholinergic function and cognitive performance, at least in part, via activation of the novel estrogen receptor GPR30. Here we evaluated the effects of estradiol, G-1 (a selective GPR30 agonist), and tamoxifen (TAM; an ERα/ERβ antagonist that also acts as a GPR30 agonist), on acetylcholine (ACh) release in the hippocampus, as well as the ability to block the effects of 17β-estradiol (E) or TAM with the GPR30 antagonist G-15. Note that… CONTINUE READING

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We have hypothesized that estradiol enhances basal forebrain cholinergic function and cognitive performance , at least in part , via activation of the novel estrogen receptor GPR30 .
We have hypothesized that estradiol enhances basal forebrain cholinergic function and cognitive performance , at least in part , via activation of the novel estrogen receptor GPR30 .
We have hypothesized that estradiol enhances basal forebrain cholinergic function and cognitive performance , at least in part , via activation of the novel estrogen receptor GPR30 .
EstrogensInverse is aEstradiol
We have hypothesized that estradiol enhances basal forebrain cholinergic function and cognitive performance , at least in part , via activation of the novel estrogen receptor GPR30 .
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