Role of GATA-3 in allergic diseases.

  title={Role of GATA-3 in allergic diseases.},
  author={Peter J Barnes},
  journal={Current molecular medicine},
  volume={8 5},
GATA-3 is a transcription factor that is specifically expressed in T helper 2 (Th2) cells and plays a critical role in the differentiation of Th2 cells from uncommitted CD4+ lymphocytes. In addition GATA-3 is essential for the gene expression of the cytokines IL-4, IL-5 and IL-13 that mediate allergic inflammation. In human T lymphocytes GATA-3 is normally localized to the cytoplasm, but on activation by antigen-presenting cells via the T cell receptor (CD3) and co-stimulatory receptor CD28… CONTINUE READING
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