Role of GAP-43 in sequestering phosphatidylinositol 4,5-bisphosphate to Raft bilayers.

Abstract

The lipid phosphatidylinositol 4,5-bisphosphate (PIP(2)) is critical for a number of physiological functions, and its presence in membrane microdomains (rafts) appears to be important for several of these spatially localized events. However, lipids like PIP(2) that contain polyunsaturated hydrocarbon chains are usually excluded from rafts, which are… (More)

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