Role of GABAB receptors in GABA and baclofen-induced inhibition of adult rat cerebellar interpositus nucleus neurons in vitro

@article{Chen2005RoleOG,
  title={Role of GABAB receptors in GABA and baclofen-induced inhibition of adult rat cerebellar interpositus nucleus neurons in vitro},
  author={Kun Chen and Hong-Zhao Li and Na Ye and Jun Zhang and Jian-jun Wang},
  journal={Brain Research Bulletin},
  year={2005},
  volume={67},
  pages={310-318}
}
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38 Citations
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38 Citations

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Orexins Excite Neurons of the Rat Cerebellar Nucleus Interpositus Via Orexin 2 Receptors In Vitro
TLDR
It is demonstrated that orexins excite the cerebellar IN neurons through OX2R and suggest that the central orexinergic nervous system may actively participate in motor control through its modulation on one of the final outputs of the spinocerebellum.
Function and modulation of δ-containing GABAA receptors
A REVIEW ON GAMMA-AMINOBUTYRIC ACID (GABA) AND ITS RECEPTORS
TLDR
The pharmacology of these novel subtypes of GABA receptors are expected to mediate the lateral inhibition of light responses and have been shown to inhibit transmitter release at bipolar cell terminals and may yield important therapeutic agents.
Contradictory effects of GABA-B receptor agonists on cortical epileptic afterdischarges in immature rats
Intrathecal baclofen, a GABAB receptor agonist, inhibits the expression of p-CREB and NR2B in the spinal dorsal horn in rats with diabetic neuropathic pain.
TLDR
Activation of GABAB receptor by baclofen attenuates diabetic neuropathic pain, which may partly be accomplished via down-regulating the expression of p-CREB and NR2B.
The Role of GABA Receptor Agonists in Anesthesia and Sedation
TLDR
An overview of the role that GABAAR agonists currently play in sedation and anesthesia is provided, in addition to discussing the future role of novel GABAar agonists in anesthesia and sedation.
Histamine improves rat rota-rod and balance beam performances through H2 receptors in the cerebellar interpositus nucleus
Effects of GABAB receptor antagonists CGP63360, CGP76290A and CGP76291A on learning and memory processes in rodents
TLDR
It may be concluded that the obtained results on the GABAB receptor antagonists could contribute to their pharmacological characteristics and might be of interest for potential clinical implication.
A Substituted Anilino Enaminone Acts as a Novel Positive Allosteric Modulator of GABAA Receptors in the Mouse Brain
TLDR
Clinical use of anilino enaminones as anticonvulsants in seizures and as a potential anxiolytic in mental disorders are suggested.
Allosteric Modulation of GABAA Receptors by an Anilino Enaminone in an Olfactory Center of the Mouse Brain
TLDR
This anilino enaminone KRS-5Me-4-OCF3 emerges as a candidate for clinical use as an anticonvulsant agent in the battle against epileptic seizures.
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References

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GABAB receptor activation of Purkinje cells in cerebellar slices
Pre- and postsynaptic GABAB receptors in the hippocampus have different pharmacological properties
Potentiation of gamma-aminobutyric acid-mediated inhibition by isoproterenol in the cerebellar cortex: Receptor specificity
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TLDR
The autoradiographic localization of these GABAB sites within the cerebellum is described and it is shown that, unlike GABAA sites, they are confined almost exclusively to the molecular layer.
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A physiological role for GABAB receptors and the effects of baclofen in the mammalian central nervous system
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