Role of GABAB receptor in alcohol dependence: Reducing effect of baclofen on alcohol intake and alcohol motivational properties in rats and amelioration of alcohol withdrawal syndrome and alcohol craving in human alcoholics

@article{Colombo2004RoleOG,
  title={Role of GABAB receptor in alcohol dependence: Reducing effect of baclofen on alcohol intake and alcohol motivational properties in rats and amelioration of alcohol withdrawal syndrome and alcohol craving in human alcoholics},
  author={Giancarlo Colombo and Giovanni Addolorato and R Agabio and Mauro A. M. Carai and Fabio Pibiri and Salvatore Serra and Giovanni Vacca and Gian Luigi Gessa},
  journal={Neurotoxicity Research},
  year={2004},
  volume={6},
  pages={403-414}
}
The present paper describes the results of recent preclinical and clinical studies conducted in this laboratory in order to characterize the anti-alcohol properties of the GABAB receptor agonist, baclofen. At a preclinical level, the repeated administration of non-sedative doses of baclofen dose-dependently suppressed the acquisition and maintenance of alcohol drinking behavior in selectively bred Sardinian alcohol-preferring (sP) rats tested under the homecage, 2-bottle “alcohol vs water… CONTINUE READING
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