Role of GABAA receptors in the physiology and pharmacology of sleep.

@article{WinskySommerer2009RoleOG,
  title={Role of GABAA receptors in the physiology and pharmacology of sleep.},
  author={Rapha{\"e}lle Winsky-Sommerer},
  journal={The European journal of neuroscience},
  year={2009},
  volume={29 9},
  pages={1779-94}
}
Most sedative-hypnotics used in insomnia treatment target the gamma-aminobutyric acid (GABA)(A) receptors. A vast repertoire of GABA(A) receptor subtypes has been identified and displays specific electrophysiological and functional properties. GABA(A)-mediated inhibition traditionally refers to 'phasic' inhibition, arising from synaptic GABA(A) receptors which transiently inhibit neurons. However, there is growing evidence that peri- or extra-synaptic GABA(A) receptors are continuously… CONTINUE READING