Role of GABAA/benzodiazepine receptors containing α1 and α5 subunits in the discriminative stimulus effects of triazolam in squirrel monkeys

@article{Lelas2002RoleOG,
  title={Role of GABAA/benzodiazepine receptors containing α1 and α5 subunits in the discriminative stimulus effects of triazolam in squirrel monkeys},
  author={Snjezana Lelas and James K. Rowlett and Roger D. Spealman and James M Cook and Chunrong Ma and Xiao-yan Li and Wenyuan Yin},
  journal={Psychopharmacology},
  year={2002},
  volume={161},
  pages={180-188}
}
Rationale: Conventional benzodiazepines (BZs), clinically used for treatment of anxiety and insomnia, bind to GABAA receptors containing α1, α2, α3, or α5 subunits. The role of these different GABAA receptor subtypes in mediating the subjective effects of BZs remains largely unknown. Objective: The purpose of the present study was to evaluate the role of GABAA receptors containing the α1 or α5 subunits in the discriminative stimulus (DS) effects of the conventional BZ agonist triazolam. Methods… CONTINUE READING