Role of GABA-active neurosteroids in the efficacy of metyrapone against cocaine addiction

@article{Schmoutz2014RoleOG,
  title={Role of GABA-active neurosteroids in the efficacy of metyrapone against cocaine addiction},
  author={Christopher D. Schmoutz and G. Guerin and N. Goeders},
  journal={Behavioural Brain Research},
  year={2014},
  volume={271},
  pages={269-276}
}
  • Christopher D. Schmoutz, G. Guerin, N. Goeders
  • Published 2014
  • Psychology, Medicine
  • Behavioural Brain Research
  • Previous research has demonstrated a complicated role for stress and HPA axis activation in potentiating various cocaine-related behaviors in preclinical models of drug dependence. However, the investigation of several antiglucocorticoid therapies has yielded equivocal results in reducing cocaine-related behaviors, possibly because of varying mechanisms of actions. Specifically, research suggests that metyrapone (a corticosterone synthesis inhibitor) may reduce cocaine self-administration in… CONTINUE READING
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