Role of GABA(A) receptors in the ethanol-mediated inhibition of extracellular signal-regulated kinase.

@article{Kalluri2002RoleOG,
  title={Role of GABA(A) receptors in the ethanol-mediated inhibition of extracellular signal-regulated kinase.},
  author={Haviryaji S. G. Kalluri and Maharaj K. Ticku},
  journal={European journal of pharmacology},
  year={2002},
  volume={451 1},
  pages={51-4}
}
In the present study, we demonstrate the involvement of GABA(A) receptors in the ethanol-mediated modulation of extracellular signal-regulated kinases (ERK). Intraperitoneal (i.p.) administration of ethanol (3.5 g), flurazepam (75 mg) or (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cycloheptane-5,10-iminemaleate (MK-801) (0.4 mg/kg body weight) decreased, while picrotoxin (10 mg/kg body weight) increased, the phosphorylation of ERK following 10 min of their injection. However, the picrotoxin… CONTINUE READING