Role of G protein-coupled receptor kinases in glucose-dependent insulinotropic polypeptide receptor signaling.

@article{Tseng2000RoleOG,
  title={Role of G protein-coupled receptor kinases in glucose-dependent insulinotropic polypeptide receptor signaling.},
  author={C C Tseng and Xi Yi Zhang},
  journal={Endocrinology},
  year={2000},
  volume={141 3},
  pages={
          947-52
        }
}
The glucose-dependent insulinotropic polypeptide receptor (GIPR) is a member of class II G protein-coupled receptors. Recent studies have suggested that desensitization of the GIPR might contribute to impaired insulin secretion in type II diabetic patients, but the molecular mechanisms of GIPR signal termination are unknown. Using HEK L293 cells stably transfected with GIPR complementary DNA (L293-GIPR), the mechanisms of GIPR desensitization were investigated. GIP dose dependently increased… CONTINUE READING
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