Role of Frataxin, a Protein Implicated in Friedreich Ataxia, in Making Iron-Sulfur Clusters♦

@article{2013RoleOF,
  title={Role of Frataxin, a Protein Implicated in Friedreich Ataxia, in Making Iron-Sulfur Clusters♦},
  author={},
  journal={The Journal of Biological Chemistry},
  year={2013},
  volume={288},
  pages={36787 - 36787}
}
  • Published 2013
  • The Journal of Biological Chemistry
Frataxin is a mitochondrial protein involved in making iron-sulfur clusters. Deficiencies in frataxin lead to the disease Friedreich ataxia, but frataxin’s precise role in Fe-S cluster biogenesis is unclear. The sulfur required for Fe-S cluster synthesis is derived from the amino acid cysteine by the cysteine desulfurase activity of Nfs1. In this Paper of the Week, Debkumar Pain at Rutgers University and colleagues used purified proteins and isolated mitochondria to show that the yeast frataxin… Expand