Role of Foxl2 in uterine maturation and function.

  title={Role of Foxl2 in uterine maturation and function.},
  author={Brice Bellessort and Anne Brouwer Bachelot and {\'E}glantine Heude and Gladys Alfama and Anastasia Fontaine and Marine Le Cardinal and Mathias Treier and Giovanni Levi},
  journal={Human molecular genetics},
  volume={24 11},
Foxl2 codes for a forkhead/HNF3 transcription factor essential for follicular maturation and maintenance of ovarian identity. FOXL2 mutations are associated with Blepharophimosis, Ptosis and Epicanthus inversus Syndrome (BPES) characterized by eyelid malformations (types I and II) and premature ovarian insufficiency (type I). We show that Foxl2 is not only expressed by the ovary, but also by other components of the mouse female reproductive tract, including the uterus, the cervix and the… CONTINUE READING


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