Role of Filia, a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesis.

@article{Zheng2009RoleOF,
  title={Role of Filia, a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesis.},
  author={Ping Zheng and Jurrien Dean},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 18},
  pages={7473-8}
}
During oogenesis, mammalian eggs accumulate proteins required for early embryogenesis. Although limited data suggest a vital role of these maternal factors in chromatin reprogramming and embryonic genome activation, the full range of their functions in preimplantation development remains largely unknown. Here we report a role for maternal proteins in maintaining chromosome stability and euploidy in early-cleavage mouse embryogenesis. Filia, expressed in growing oocytes, encodes a protein that… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 49 references

Targeted disruption of Aurora A causes abnormal mitotic spindle assembly, chromosome misalignment and embryonic lethality

K Sasai
Oncogene • 2008

Causes of fetal wastage.

Clinical obstetrics and gynecology • 2007

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