Role of Fatty Acid Composition in the Development of Metabolic Disorders in Sucrose-Induced Obese Rats

@article{Fukuchi2004RoleOF,
  title={Role of Fatty Acid Composition in the Development of Metabolic Disorders in Sucrose-Induced Obese Rats},
  author={S. Fukuchi and K. Hamaguchi and M. Seike and K. Himeno and T. Sakata and H. Yoshimatsu},
  journal={Experimental Biology and Medicine},
  year={2004},
  volume={229},
  pages={486 - 493}
}
Fatty acids have been shown to be involved in the development of insulin resistance associated with obesity. We used sucrose loading in rats to analyze changes in fatty acid composition in the progression of obesity and the related metabolic disorder. Although rats fed a sucrose diet for 4 weeks had body weights similar to those of control animals, their visceral fat pads were significantly larger, and serum triglyceride levels were higher; however, neither plasma glucose nor insulin levels… Expand
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References

SHOWING 1-10 OF 29 REFERENCES
Effect of Dietary Fish Oil on Insulin Sensitivity and Metabolic Fate of Glucose in the Skeletal Muscle of Normal Rats
TLDR
The results show that dietary fish oil decreases plasma insulin levels without alteration in glucose homeostasis (at baseline) and the observed enhancement in whole body glucose utilization during clamping suggests an increased peripheral insulin sensitivity. Expand
Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity.
TLDR
The casual relationship between intraabdominal visceral fat accumulation and metabolic disorders was analyzed in 46 obese subjects and found to be significant after adjustment for BMI and age by multiple regression analyses. Expand
Insulin resistance directly correlates with increased saturated fatty acids in skeletal muscle triglycerides.
TLDR
Not only the MTG concentration but also the FFA pattern seems to affect insulin-mediated glucose uptake, and a pivotal role might be played by a high saturated fatty acid content in the TGs. Expand
Improvement of glucose and lipid metabolism associated with selective reduction of intra-abdominal visceral fat in premenopausal women with visceral fat obesity.
TLDR
Analysis of fat distribution by CT scanning demonstrated that visceral fat decreased to a greater extent than abdominal subcutaneous fat, which was particularly evident in VFO patients, and partial correlation analyses demonstrated that the metabolic improvements were associated with changes in visceral abdominal fat after control for changes in total adipose tissue volume. Expand
Serum phospholipid fatty acid composition and insulin action in type 2 diabetic patients
Relationships have been demonstrated between insulin sensitivity and the fatty acid (FA) composition of serum and tissue lipids in adult humans. The present study aimed to investigate the above… Expand
The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids.
BACKGROUND Insulin resistance and hyperinsulinemia are features of obesity, non-insulin-dependent diabetes mellitus, and other disorders. Skeletal muscle is a major site of insulin action, and… Expand
Rapid enhancement of acyl-CoA synthetase, LPL, and GLUT-4 mRNAs in adipose tissue of VMH rats.
TLDR
It is concluded that ACS, GLUT-4, and LPL may contribute to fat accumulation at the gene expression level from a very early stage during the development of obesity. Expand
Changes in phosphatidylcholine fatty acid composition are associated with altered skeletal muscle insulin responsiveness in normal man.
TLDR
These studies suggest that the induction of insulin resistance with NA is associated with changes in the fatty acid composition of PC in man. Expand
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.
TLDR
It is concluded that acute elevations of plasma FFA levels for 5 h induce skeletal muscle insulin resistance in vivo via a reduction in insulin-stimulated muscle glycogen synthesis and glucose oxidation that can be attributed to reduced glucose transport activity. Expand
Uncoupling of Obesity from Insulin Resistance Through a Targeted Mutation in aP2, the Adipocyte Fatty Acid Binding Protein
TLDR
Results indicate that aP2 is central to the pathway that links obesity to insulin resistance, possibly by linking fatty acid metabolism to expression of TNF-α. Expand
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