Role of Fas (CD95) in tubulointerstitial disease induced by unilateral ureteric obstruction.

  title={Role of Fas (CD95) in tubulointerstitial disease induced by unilateral ureteric obstruction.},
  author={Jeremy Hughes and Richard J Johnson},
  journal={American journal of physiology. Renal physiology},
  volume={277 1},
Murine renal tubular epithelial cells and interstitial fibroblasts may express both Fas (CD95) death receptor and Fas ligand and are vulnerable to Fas-mediated death in vitro. We therefore hypothesized that an absence of renal Fas may protect resident cells from undergoing apoptosis. We performed unilateral ureteric ligation [producing unilateral ureteral obstruction (UUO)] in 6-wk-old normal control mice and C57Bl6/ lpr mice, which express a nonfunctional Fas receptor. Obstructed kidneys were… CONTINUE READING


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