Role of FTO in Adipocyte Development and Function: Recent Insights.

@article{Merkestein2015RoleOF,
  title={Role of FTO in Adipocyte Development and Function: Recent Insights.},
  author={Myrte Merkestein and Dyan Sellayah},
  journal={International journal of endocrinology},
  year={2015},
  volume={2015},
  pages={
          521381
        }
}
In 2007, FTO was identified as the first genome-wide association study (GWAS) gene associated with obesity in humans. Since then, various animal models have served to establish the mechanistic basis behind this association. Many earlier studies focussed on FTO's effects on food intake via central mechanisms. Emerging evidence, however, implicates adipose tissue development and function in the causal relationship between perturbations in FTO expression and obesity. The purpose of this mini… CONTINUE READING

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