Role of FLT3 in leukemia.

  title={Role of FLT3 in leukemia.},
  author={Dwight Gary Gilliland and James D Griffin},
  journal={Current opinion in hematology},
  volume={9 4},
FLT3 is the most frequently mutated gene in cases of acute myelogenous leukemia (AML). About 30 to 35% of patients have either internal tandem duplications (ITDs) in the juxtamembrane domain or mutations in the activating loop of FLT3. FLT3 mutations occur in a broad spectrum of FAB subtypes in adult and pediatric AML and are particularly common in acute… CONTINUE READING