Role of European mitochondrial DNA haplogroups in the prevalence of hip osteoarthritis in Galicia, Northern Spain

@article{Rego2010RoleOE,
  title={Role of European mitochondrial DNA haplogroups in the prevalence of hip osteoarthritis in Galicia, Northern Spain},
  author={Ignacio Rego and Mercedes Fern{\'a}ndez-Moreno and Carlos Fern{\'a}ndez-L{\^o}pez and Juan J G{\'o}mez-Reino and A. Gonz{\'a}lez and Joaquı́n Arenas and Francisco J. Blanco},
  journal={Annals of the Rheumatic Diseases},
  year={2010},
  volume={69},
  pages={210 - 213}
}
Objective: To analyse the mitochondrial DNA (mtDNA) haplogroups of patients with hip osteoarthritis (OA) and those of healthy controls in a Spanish population. Methods: mtDNA haplogroups were assigned to 550 cases of hip OA and 505 clinically asymptomatic controls. Sets of controls with healthy knees and hips (n = 179) and patients with knee and/or hip OA (n = 977) were also analysed in a multivariate analysis after adjusting for sex, age and smoking. Results: Individuals carrying haplogroup J… Expand
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References

SHOWING 1-10 OF 19 REFERENCES
Mitochondrial DNA haplogroups: role in the prevalence and severity of knee osteoarthritis.
TLDR
People carrying haplogroups J and U may be at a lower risk of developing knee OA, and those carrying this haplogroup in whom knees OA does not develop may have a less severe progression of the disease. Expand
New evidence of a mitochondrial genetic background paradox: Impact of the J haplogroup on the A3243G mutation
TLDR
This study supports the existence of mutational hotspot on mtDNA and a "haplogroup J paradox," a haplogroup that may increase the expression of mtDNA pathogenic mutations, but also be beneficial in certain environmental contexts. Expand
Further evidence of the role of frizzled-related protein gene polymorphisms in osteoarthritis
TLDR
The results suggest that the R324G SNP of the FRZB gene may have an effect in OA development in multiple joints, with a specific severe involvement of the hip in women. Expand
Classification of European mtDNAs from an analysis of three European populations.
TLDR
The conclusion that most haplogroups observed in Europe are Caucasoid-specific, and that at least some of them occur at varying frequencies in different Caucasoid populations, is supported. Expand
An evolutionary perspective on pathogenic mtDNA mutations: haplogroup associations of clinical disorders.
TLDR
It is suggested that, a haplogroup-group association must be detected in multiple subpopulations or in a large, carefully controlled population survey to draw broad conclusions on the basis of the available evidence. Expand
Natural selection shaped regional mtDNA variation in humans
TLDR
It is concluded that selection may have played a role in shaping human regional mtDNA variation and that one of the selective influences was climate. Expand
Mitochondrial respiratory activity is altered in osteoarthritic human articular chondrocytes.
TLDR
Findings suggest the involvement of mitochondrial function in the pathophysiology of OA, where cartilage degradation by OA and cartilage aging may be two different processes. Expand
Effects of Purifying and Adaptive Selection on Regional Variation in Human mtDNA
TLDR
A phylogenetic analysis of 1125 global human mitochondrial DNA sequences permitted positioning of all nucleotide substitutions according to their order of occurrence, and particularly highly conserved amino acid substitutions were found at the roots of multiple mtDNA lineages from higher latitudes. Expand
Control region mtDNA variants: Longevity, climatic adaptation, and a forensic conundrum
TLDR
A new twist was added in a recent issue of PNAS, an mtDNA mutation that promotes longevity in association with the accumulation of somatic mtDNA rearrangement and base substitution mutations. Expand
Mitochondrial diseases in man and mouse.
TLDR
The essential role of mitochondrial oxidative phosphorylation in cellular energy production, the generation of reactive oxygen species, and the initiation of apoptosis has suggested a number of novel mechanisms for mitochondrial pathology. Expand
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