Role of Escherichia coli YbeY, a highly conserved protein, in rRNA processing.

@article{Davies2010RoleOE,
  title={Role of Escherichia coli YbeY, a highly conserved protein, in rRNA processing.},
  author={Bryan Davies and Caroline K{\"o}hrer and Asha Ivy Jacob and Lyle A Simmons and Jianyu Zhu and Lourdes M. Aleman and Uttam L. RajBhandary and Graham C Walker},
  journal={Molecular microbiology},
  year={2010},
  volume={78 2},
  pages={506-18}
}
The UPF0054 protein family is highly conserved with homologues present in nearly every sequenced bacterium. In some bacteria, the respective gene is essential, while in others its loss results in a highly pleiotropic phenotype. Despite detailed structural studies, a cellular role for this protein family has remained unknown. We report here that deletion of the Escherichia coli homologue, YbeY, causes striking defects that affect ribosome activity, translational fidelity and ribosome assembly… CONTINUE READING