Role of Erythrogenin from Liver and Spleen in Erythropoietin Production in the Anephric Rat

IT is well established that the kidney is the main site of the production and/or activation of erythropoietin (Ep)1,2. Gordon et al.3 have presented evidence indicating that under both normal and hypoxic conditions the production of circulating Ep involves the interaction of a renal erythropoietic factor (also termed erythrogenin) with a serum protein… CONTINUE READING