Role of ErbB family receptor tyrosine kinases in intrahepatic cholangiocarcinoma.

@article{Sirica2008RoleOE,
  title={Role of ErbB family receptor tyrosine kinases in intrahepatic cholangiocarcinoma.},
  author={Alphonse E. Sirica},
  journal={World journal of gastroenterology},
  year={2008},
  volume={14 46},
  pages={7033-58}
}
Aberrant expression and signaling of epidermal growth factor receptor (ErbB) family receptor tyrosine kinases, most notably that of ErbB2 and ErbB1, have been implicated in the molecular pathogenesis of intrahepatic cholangiocarcinoma. Constitutive overexpression of ErbB2 and/or ErbB1 in malignant cholangiocytes has raised interest in the possibility that agents which selectively target these receptors could potentially be effective in cholangiocarcinoma therapy. However, current experience… CONTINUE READING

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