Role of Epiprofin, a zinc-finger transcription factor, in limb development.

@article{Talamillo2010RoleOE,
  title={Role of Epiprofin, a zinc-finger transcription factor, in limb development.},
  author={Ana Talamillo and I. Delgado and Takashi Nakamura and Susana de-Vega and Yasuo Yoshitomi and Fernando J. Unda and Walter Birchmeier and Yoshihiko Yamada and Marian A Ros},
  journal={Developmental biology},
  year={2010},
  volume={337 2},
  pages={363-74}
}
The formation and maintenance of the apical ectodermal ridge (AER) is critical for the outgrowth and patterning of the vertebrate limb. In the present work, we have investigated the role of Epiprofin (Epfn/Sp6), a member of the SP/KLF transcription factor family that is expressed in the limb ectoderm and the AER, during limb development. Epfn mutant mice have a defective autopod that shows mesoaxial syndactyly in the forelimb and synostosis (bony fusion) in the hindlimb and partial bidorsal… CONTINUE READING
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