Role of Energy Metabolism in the Brown Fat Gene Program

  title={Role of Energy Metabolism in the Brown Fat Gene Program},
  author={Minwoo Nam and Marcus P. Cooper},
  booktitle={Front. Endocrinol.},
In murine and human brown adipose tissue (BAT), mitochondria are powerful generators of heat that safely metabolize fat, a feature that has great promise in the fight against obesity and diabetes. Recent studies suggest that the actions of mitochondria extend beyond their conventional role as generators of heat. There is mounting evidence that impaired mitochondrial respiratory capacity is accompanied by attenuated expression of Ucp1 and other BAT-selective genes, implying that mitochondria… CONTINUE READING
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