Role of ET-1 in the regulation of coronary circulation.

  title={Role of ET-1 in the regulation of coronary circulation.},
  author={Michel Lavall{\'e}e and Eric Thorin},
  journal={Canadian journal of physiology and pharmacology},
  volume={81 6},
Given that circulating ET levels in heart failure, in particular, may reach physiological threshold for coronary constrictor responses, the primary objective of the present review is to consider coronary vessels as an important target for circulating and locally produced endothelin(s). In healthy vessels, ET-1 causes biphasic coronary responses characterized by a transient dilation of large and small arteries followed by a sustained constriction. ETB receptors are pivotal in the early dilation… CONTINUE READING
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