Role of ERK1/2 and PI3-K in the regulation of CTGF-induced ILK expression in HK-2 cells.

Abstract

BACKGROUND Previous studies revealed that integrin-linked kinase (ILK), an intracellular serine/threonine protein kinase, is a critical mediator for tubular epithelial to mesenchymal transition (EMT), and likely plays an important role in the pathogenesis of chronic kidney fibrosis. However, the exact signal pathway has not been well understood. In this… (More)

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