Role of ERK signaling in the neuroprotective efficacy of magnesium sulfate treatment during focal cerebral ischemia in the gerbil cortex.

@article{Huang2010RoleOE,
  title={Role of ERK signaling in the neuroprotective efficacy of magnesium sulfate treatment during focal cerebral ischemia in the gerbil cortex.},
  author={Chih-Yang Huang and Yi-Fan Liou and S Chung and Wen-yuan Lin and Gwo-Ping Jong and Chia-Hua Kuo and Fuu-Jen Tsai and Yi-Chang Cheng and Fu-chou Cheng and Jing-Ying Lin},
  journal={The Chinese journal of physiology},
  year={2010},
  volume={53 5},
  pages={299-309}
}
Magnesium sulfate (MgSO4) ameliorates focal ischemia-induced neuronal death in the rat and gerbil models. However, the molecular mechanisms for this neuroprotection are not known. Focal cerebral ischemia was produced by unilateral occlusion of the right common carotid artery and the right middle cerebral artery (CCAO + MCAO) for 30 min or 60 min. Treatment with MgSO4 significantly increased the level of mitogen-activated protein kinase/extra-cellular signal-regulated kinase kinase 1/2 (MEK1/2… CONTINUE READING