Role of ERK-BIM and STAT3-survivin signaling pathways in ALK inhibitor-induced apoptosis in EML4-ALK-positive lung cancer.

@article{Takezawa2011RoleOE,
  title={Role of ERK-BIM and STAT3-survivin signaling pathways in ALK inhibitor-induced apoptosis in EML4-ALK-positive lung cancer.},
  author={Ken Takezawa and Isamu Okamoto and Kazuto Nishio and Pasi Antero J{\"a}nne and Kazuhiko Nakagawa},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2011},
  volume={17 8},
  pages={2140-8}
}
PURPOSE EML4-ALK (echinoderm microtubule-associated protein-like 4 anaplastic lymphoma kinase) was recently identified as a transforming fusion gene in non-small cell lung cancer. The purpose of the present study was to characterize the mechanism of malignant transformation by EML4-ALK. EXPERIMENTAL DESIGN We established NIH 3T3 cells that stably express variant 1 or 3 of EML4-ALK and examined the signaling molecules that function downstream of EML4-ALK. RESULTS Forced expression of EML4… CONTINUE READING

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