Role of ERK/mTOR signaling in TGFβ-modulated focal adhesion kinase mRNA stability and protein synthesis in cultured rat IEC-6 intestinal epithelial cells

@article{Suer2009RoleOE,
  title={Role of ERK/mTOR signaling in TGFβ-modulated focal adhesion kinase mRNA stability and protein synthesis in cultured rat IEC-6 intestinal epithelial cells},
  author={Silke Suer and Dinakar R. Ampasala and Mary F. Walsh and Marc D. Basson},
  journal={Cell and Tissue Research},
  year={2009},
  volume={336},
  pages={213-223}
}
Increasing evidence is available showing the importance of the FAK (focal adhesion kinase) protein level in the migration and homeostasis of intestinal cells. TGFβ (transforming growth factor beta) modulates FAK protein expression in a complex fashion not only by inducing the activation of p38 and Smad signaling resulting in increased fak promoter activity and increased FAK protein levels, but also by activating ERK (extracellular signal regulated kinases), p38, and the Smad pathway. We show… CONTINUE READING
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