Role of ERα in Mediating Female Uterine Transcriptional Responses to IGF1

@inproceedings{Hewitt2017RoleOE,
  title={Role of ERα in Mediating Female Uterine Transcriptional Responses to IGF1},
  author={Sylvia C Hewitt and Wipawee Winuthayanon and Sydney L. Lierz and Katherine J. Hamilton and Lauren J. Donoghue and Jeffery Tyler Ramsey and Sara A. Grimm and Yukitomo Arao and Kenneth S. Korach},
  booktitle={Endocrinology},
  year={2017}
}
Estrogen (E2) signaling through its nuclear receptor, E2 receptor α (ERα) increases insulinlike growth factor 1 (IGF1) in the rodent uterus, which then initiates further signals via the IGF1 receptor. Directly administering IGF1 results in similar biological and transcriptional uterine responses. Our studies using global ERα-null mice demonstrated a loss of uterine biological responses of the uterus to E2 or IGF1 treatment, while maintaining transcriptional responses to IGF1. To address this… CONTINUE READING
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