Role of EETs in regulation of endothelial permeability in rat lung.

@article{Alvarez2004RoleOE,
  title={Role of EETs in regulation of endothelial permeability in rat lung.},
  author={Diego F. Alvarez and E A Gjerde and Mary I. Townsley},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2004},
  volume={286 2},
  pages={L445-51}
}
This study tested the hypothesis that epoxyeicosatrienoic acids (EETs) derived from arachidonic acid via P-450 epoxygenases are soluble factors linking depletion of endoplasmic reticulum Ca(2+) stores and store-dependent regulation of endothelial cell (EC) permeability in rat lung. EC permeability was measured via the capillary filtration coefficient (K(f,c)) in isolated, perfused rat lungs. 14,15-EET and 5,6-EET increased EC permeability, a response that was significantly different from that… CONTINUE READING

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Pathways of L450 EETS AND ACUTE LUNG INJURY

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1 Excerpt

14,15-Epoxyeicosatrienoic acid activates store-operated calcium channels in rat pulmonary microvascular endothelial cells (Abstract)

  • EB Gjerde, T Stevens, MI. Townsley
  • FASEB J late-breaking abstracts:
  • 2003
1 Excerpt

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