Role of Dorsal Medial Prefrontal Cortex Dopamine D1-Family Receptors in Relapse to High-Fat Food Seeking Induced by the Anxiogenic Drug Yohimbine

@article{Nair2011RoleOD,
  title={Role of Dorsal Medial Prefrontal Cortex Dopamine D1-Family Receptors in Relapse to High-Fat Food Seeking Induced by the Anxiogenic Drug Yohimbine},
  author={Sunila G. Nair and Brittany M. Navarre and Carlo Cifani and Charles L. Pickens and Jennifer M Bossert and Yavin Shaham},
  journal={Neuropsychopharmacology},
  year={2011},
  volume={36},
  pages={497-510}
}
In humans, relapse to maladaptive eating habits during dieting is often provoked by stress. In rats, the anxiogenic drug yohimbine, which causes stress-like responses in both humans and nonhumans, reinstates food seeking in a relapse model. In this study, we examined the role of medial prefrontal cortex (mPFC) dopamine D1-family receptors, previously implicated in stress-induced reinstatement of drug seeking, in yohimbine-induced reinstatement of food seeking. We trained food-restricted rats to… CONTINUE READING
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