Role of Dopamine Receptors in ADHD: A Systematic Meta-analysis

@article{Wu2012RoleOD,
  title={Role of Dopamine Receptors in ADHD: A Systematic Meta-analysis},
  author={Jing Wu and Haifan Xiao and Hongjuan Sun and Li Zou and Ling-Qiang Zhu},
  journal={Molecular Neurobiology},
  year={2012},
  volume={45},
  pages={605-620}
}
The dopaminergic system plays a pivotal role in the central nervous system via its five diverse receptors (D1–D5). Dysfunction of dopaminergic system is implicated in many neuropsychological diseases, including attention deficit hyperactivity disorder (ADHD), a common mental disorder that prevalent in childhood. Understanding the relationship of five different dopamine (DA) receptors with ADHD will help us to elucidate different roles of these receptors and to develop therapeutic approaches of… 

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References

SHOWING 1-10 OF 243 REFERENCES
Polymorphisms of the dopamine D4 receptor, clinical outcome, and cortical structure in attention-deficit/hyperactivity disorder.
TLDR
The DRD4 7-repeat allele, which is widely associated with a diagnosis of ADHD, and in this cohort with better clinical outcome, is associated with cortical thinning in regions important in attentional control.
Dopaminergic System Genes in ADHD: Toward a Biological Hypothesis
Evidence that the dopamine D4 receptor is a susceptibility gene in attention deficit hyperactivity disorder
TLDR
Family, twin, and adoption studies suggest genetic factors contribute to ADHD and symptoms of inattention, impulsivity, and hyperactivity.
Linkage of the dopamine D4 receptor gene and attention-deficit/hyperactivity disorder.
TLDR
The results of this study further support the possibility of a role of the dopamine D4 receptor locus in ADHD.
Structure and function of dopamine receptors
Examining for association between candidate gene polymorphisms in the dopamine pathway and attention-deficit hyperactivity disorder: a family-based study.
TLDR
It is concluded that none of the alleles tested makes a major contribution to ADHD, although much larger samples are required to exclude small effects.
The Dopamine Theory of Attention Deficit Hyperactivity Disorder (ADHD)
  • F. Lévy
  • Psychology, Medicine
    The Australian and New Zealand journal of psychiatry
  • 1991
TLDR
The dopamine hypothesis of Attention Deficit Hyperactivity Disorder (ADHD) is examined from the point of view of differential dose effects of CNS stimulant medications, and theories of neural control.
...
1
2
3
4
5
...