Role of Dok-1 and Dok-2 in Myeloid Homeostasis and Suppression of Leukemia

  title={Role of Dok-1 and Dok-2 in Myeloid Homeostasis and Suppression of Leukemia},
  author={Tomoharu Yasuda and Masaki Shirakata and Atsushi Iwama and Asuka Ishii and Yasuhiro Ebihara and Mitsujiro Osawa and Kazuho Honda and Hisaaki Shinohara and Katsuko Sudo and Kohichiro Tsuji and Hiromitsu Nakauchi and Yoichiro Iwakura and Hisamaru Hirai and Hideaki Oda and Tadashi Yamamoto and Yuji Yamanashi},
  journal={The Journal of Experimental Medicine},
  pages={1681 - 1687}
Dok-1 and Dok-2 are closely related rasGAP-associated docking proteins expressed preferentially in hematopoietic cells. Although they are phosphorylated upon activation of many protein tyrosine kinases (PTKs), including those coupled with cytokine receptors and oncogenic PTKs like Bcr-Abl, their physiological roles are largely unidentified. Here, we generated mice lacking Dok-1 and/or Dok-2, which included the double-deficient mice succumbed to myeloproliferative disease resembling human… CONTINUE READING
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