Role of Dok-1 and Dok-2 in Leukemia Suppression

  title={Role of Dok-1 and Dok-2 in Leukemia Suppression},
  author={Masaru Niki and Antonio Di Cristofano and Mingming Zhao and Hiroaki Honda and Hisamaru Hirai and Linda Van Aelst and Carlos Cordon-Cardo and Pier Paolo Pandolfi},
  journal={The Journal of Experimental Medicine},
  pages={1689 - 1695}
Chronic myelogenous leukemia (CML) is characterized by the presence of the chimeric p210bcr/abl oncoprotein that shows elevated and constitutive protein tyrosine kinase activity relative to the normal c-abl tyrosine kinase. Although several p210bcr/abl substrates have been identified, their relevance in the pathogenesis of the disease is unclear. We have identified a family of proteins, Dok (downstream of tyrosine kinase), coexpressed in hematopoietic progenitor cells. Members of this family… CONTINUE READING


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quired loss of p 53 induces blastic transformation in p 210 bcr / abl - expressing hematopoietic cells : a transgenic study for blast crisis of human CML

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