Role of Dictyostelium racE in cytokinesis: mutational analysis and localization studies by use of green fluorescent protein.

@article{Larochelle1997RoleOD,
  title={Role of Dictyostelium racE in cytokinesis: mutational analysis and localization studies by use of green fluorescent protein.},
  author={Denis A. Larochelle and Kalpa Vithalani and Arturo De Lozanne},
  journal={Molecular biology of the cell},
  year={1997},
  volume={8 5},
  pages={935-44}
}
The small GTPase racE is essential for cytokinesis in Dictyostelium but its precise role in cell division is not known. To determine the molecular mechanism of racE function, we undertook a mutational analysis of racE. The exogenous expression of either wild-type racE or a constitutively active V20racE mutant effectively rescues the cytokinesis deficiency of racE null cells. In contrast, a constitutively inactive N25racE mutant fails to rescue the cytokinesis deficiency. Thus, cytokinesis… CONTINUE READING
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