Role of DNA repair in host immune response and inflammation.

  title={Role of DNA repair in host immune response and inflammation.},
  author={Fabr{\'i}cia Lima Fontes and Daniele Maria Lopes Pinheiro and Ana Helena Sales de Oliveira and Rayssa Karla de Medeiros Oliveira and Tirzah Braz Petta Lajus and Lucymara F. Agnez-Lima},
  journal={Mutation research. Reviews in mutation research},
In recent years, the understanding of how DNA repair contributes to the development of innate and acquired immunity has emerged. The DNA damage incurred during the inflammatory response triggers the activation of DNA repair pathways, which are required for host-cell survival. Here, we reviewed current understanding of the mechanism by which DNA repair contributes to protection against the oxidized DNA damage generated during infectious and inflammatory diseases and its involvement in innate and… CONTINUE READING
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