Role of DNA methylation in the nucleus accumbens in incubation of cocaine craving.

@article{Massart2015RoleOD,
  title={Role of DNA methylation in the nucleus accumbens in incubation of cocaine craving.},
  author={Renaud Massart and Royi Barnea and Yahav Dikshtein and Matthew J. Suderman and Oren Meir and Michael T. Hallett and Pamela J. Kennedy and Eric J Nestler and Moshe Szyf and Gal Yadid},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2015},
  volume={35 21},
  pages={8042-58}
}
One of the major challenges of cocaine addiction is the high rate of relapse to drug use after periods of withdrawal. During the first few weeks of withdrawal, cue-induced cocaine craving intensifies, or "incubates," and persists over extended periods of time. Although several brain regions and molecular mechanisms were found to be involved in this process, the underlying epigenetic mechanisms are still unknown. Herein, we used a rat model of incubation of cocaine craving, in which rats were… CONTINUE READING